The DOriS project explored new self-assembly paradigms for realizing extended, yet non-crystalline, structures based on DNA supraparticles. The project’s gist is to design the shape and interaction of DNA origami particles so they can form self-assemblies with exotic physical properties unachievable by conventional materials. The DOriS international team collaborated to identify candidate DNA origami that can yield meta-materials with tunable structural complexity (short- or long-range order) and mechanical properties (compressibility). To this end, we implemented advanced techniques for molecular design and molecular dynamics simulations as a virtual lab for meta-materials prototyping.